NAD+ (nicotinamide adenine dinucleotide) is a coenzyme essential for energy production, DNA repair, and overall cellular function. However, NAD+ levels naturally decline with age, contributing to issues like reduced metabolism, fatigue, and susceptibility to age-related diseases.

To counteract this decline, two key precursors—Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR)—have emerged as promising tools in longevity research. While both compounds replenish NAD+ levels, each have distinct pathways and mechanisms.

The following reference to NR is based on competing NR products to Pricera.  Pricera is considered an NR supplement but studies have demonstrated it is superior to regular NR supplements as seen in the chart at the end of this article.

I will be sending two more emails which describe in more detail clinical effectiveness and bioavailability of each.  I hope you find each informative and encourage you to contact us with questions and if you want to try Pricera in your practice.
_______________________________________________________________

Structure and Effectiveness of NR vs. NMN: A Closer Look

Structural Differences                                                                                         

  • NMN: A larger molecule consisting of nicotinamide, ribose, and a phosphate group.
  • NR: A simpler molecule with just nicotinamide linked to ribose.

Pathways to NAD+                                                                                              

  • NMN:
    • Synthesized via the salvage pathway using the enzyme NAMPT.
    • Directly absorbed by certain tissues, or converted to NR for cellular entry in others.
    • Inside the cell, converted to NAD+ by NMNAT enzymes.
  • NR:
    • Phosphorylated by NR kinases (NRK1/NRK2) to form NMN.
    • Alternatively metabolized to nicotinamide in the gut, contributing to NAD+ production.

Absorption and Tissue Specificity                                                                    

  • NMN:
    • May bypass certain conversion steps, offering tissue-specific advantages where direct absorption occurs.
  • NR:
    • Smaller size facilitates broader cellular uptake and efficient transport into cells.

Considerations for Use                                                                                       

  • Effectiveness: Both precursors effectively raise NAD+ levels, but differences in structure and metabolism influence their speed and efficiency.
  • Health Goals: The choice depends on individual health needs, whether targeting specific tissues or seeking broader NAD+ elevation.

Conclusion                                                                                                          

Understanding these distinctions empowers a more tailored approach to NAD+ supplementation. NR’s broader cellular availability and targeted benefits seems to make it the better choice over NMN’s direct tissue benefits and both serve as valuable tools in promoting cellular health and combating aging.

_________________________________________

Pricera is a Next Generation NAD booster which has been used by practitioners for the last 5 years and has benefited thousands of patients.

___________________________________________

In a head-to-head study with the leading brand. Pricera produced:

Pricera is a stable, highly bioavailable compound for increased longevity and healthy aging and the ONLY single ingredient NAD booster that targets all three aging biomarkers – NAD, Glutathione and ATP.