In this third of three part emails, we continue to look at the difference between two key NAD+ precursors—Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR).

As I mentioned before, the following information is based on competing NR products to Pricera.  Pricera is considered an NR supplement but studies have demonstrated it is superior to regular NR supplements as seen in the chart at the end of this article.

I hope you find this informative and encourage you to contact us with questions and if you want to try Pricera in your practice.

NMN vs. NR: Clinical Effectiveness Compared

Both NMN and NR demonstrate significant potential to enhance NAD+ levels and deliver health benefits, with clinical studies highlighting their safety and efficacy. Here’s a side-by-side comparison based on the available evidence:

1. Safety Profiles                                                                                                 
NR:
  • Dosage Tolerability: Well tolerated at doses up to 3000 mg/day, with no serious adverse effects reported.
  • Trials: A 6-week study at 1000 mg/day confirmed excellent safety.
  • Conclusion: NR has a strong safety record even at high doses, making it a viable option for long-term supplementation.
NMN:
  • Dosage Tolerability: Safe up to 900 mg/day, with no significant adverse effects in trials lasting up to 12 weeks.
  • Trials: Studies using 250–300 mg/day showed excellent safety and no negative health outcomes.
  • Conclusion: NMN is comparably safe and well tolerated, even at higher doses.
2. NAD+ Elevation Capabilities                                                                          
NR:
  • Efficacy: Shown to increase NAD+ levels by ~60% within six weeks at doses of 1000 mg/day.
  • Speed: Single doses of NR can elevate NAD+ levels within hours, confirming its rapid bioavailability.
  • Long-Term Use: Sustained elevations of NAD+ levels have been observed in multiple studies.
NMN:
  • Efficacy: Increases NAD+ levels significantly, even at doses as low as 300 mg/day.
  • Duration: Studies observed steady NAD+ increases over periods of 30 to 60 days.
  • Long-Term Use: Demonstrated effectiveness in maintaining elevated NAD+ levels over extended supplementation.
3. Clinical Outcomes                                                                                           
NR:
  • Metabolic Health: Improved insulin sensitivity, reduced blood pressure, and better lipid profiles.
  • Physical Performance: Enhanced walking distance in six-minute walk tests, showing functional benefits.
  • Cardiovascular Health: Positive effects on cardiovascular markers, including arterial health.
NMN:
  • Metabolic Health: Reduced arterial stiffness and improved cardiovascular function.
  • Physical Performance: Increased walking distance and better exercise test results.
  • Other Benefits: NMN’s tissue-specific effects, such as cardiovascular health improvements, suggest unique advantages.
Key Takeaways                                                                                                    
  1. Both are Safe: Clinical trials confirm that both NR and NMN are safe for human consumption, even at high doses.
  2. Rapid vs. Sustained Action: NR’s rapid bioavailability makes it ideal for quick NAD+ boosts, while NMN provides steady, long-term elevation.
  3. Health Outcomes: Both precursors improve metabolic and cardiovascular health, with overlapping but distinct benefits.
  4. Individual Choice: The choice between NMN and NR may depend on specific health goals, budget, and individual response.

Conclusion                                                                                                           

Neither precursor is inherently “better” in all contexts. NR may may have the advantage because it suits individuals seeking rapid NAD+ boosts and has broader metabolic benefits, while NMN could appeal to those targeting specific outcomes, such as cardiovascular health or tissue-specific effects…which NR also addresses.

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Pricera is a Next Generation NAD booster which has been used by practitioners for the last 5 years and has benefited thousands of patients.

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In a head-to-head study with the leading brand. Pricera produced:

Pricera is a stable, highly bioavailable compound for increased longevity and healthy aging and the ONLY single ingredient NAD booster that targets all three aging biomarkers – NAD, Glutathione and ATP.