Although proper supplementation can help, depression can really take hold for many. Let’s be mindful of others and reach out when you see someone who may be a little “off”.
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Optimizing NAD levels yields nine crucial benefits for robust health. NAD+ sustains sirtuin enzymes which are vital for health and disease prevention. They also play a major role in depression and anxiety.

Sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes.

In a study examining depression, SIRTs were demonstrated to be therapeutic targets for the following reasons:

  1. SIRTs may control the inflammatory response in depression

  2. SIRTs might regulate the insufficient level of neurotransmitters in depression

  3. SIRTs may improve the synaptic dysfunction caused by depression

  4. Sirtuins may alleviate the cognitive decline caused by depression

Song J and Kim J. Role of Sirtuins in Linking Metabolic Syndrome with Depression. Front. Cell. Neurosci. 10:86. doi: 10.3389/fncel.2016.00086.

Sirtuins are activated by high NAD+ levels and act as intracellular NAD+ sensors. Numerous studies have shown that enhancing NAD+ availability can be used to activate SIRTs and promote beneficial health effects such as the ones cited above.

Integra Nutrition – Longevity Sciences is an award winning brand natural health practitioners have trusted for over 25 years. Our products are Healthy Aging supplement solutions. Numerous studies and 6 years of use by practitioners globally have shown that PRICERA NAD+ Precursor is arguably the best supplement to raise NAD+ levels.