PRICERA is a proprietary compound shown to enter the NAD+ biosynthetic pathway directly, efficiently increasing NAD+ levels throughout the body, including muscle and brain tissues. Study conducted by: American Preclinical Services, Minneapolis, MN; Alex Xue, PhD, BioE Life Science, Inc., Minneapolis, MN.

Key Findings

1. Pharmacodynamics of PRICERA

  • Study Design: PRICERA metabolites, including NAD+, NMN, and NR, were measured daily in the blood over a five-day period. Animals were supplemented orally with test articles twice daily.
  • NAD+ Levels: Steady, dose-dependent increase in NAD+ levels, reaching a plateau after four days (8 doses) of supplementation (Figure 2).
  • NR Levels: Increased similarly to NAD+, though on a smaller scale, consistent with NR being an overflow shunt product in NAD+ biosynthesis.
  • NMN Levels: No significant change in blood levels, aligning with existing research.

2. Tissue Distribution of PRICERA Metabolites

  • Post-Supplementation Analysis: After five days, tissues were harvested and analyzed for NAD+ metabolite content.
  • Highest NAD+ Levels: Detected in the liver, which also has the highest background NAD+ levels.
  • Other Tissues: Brain had the second-largest NAD+ pools, followed closely by muscle.
  • Positive Dose-Response: Observed between PRICERA dosage and NAD+ metabolite content across all analyzed organs and tissues.

Insights

  • Blood and Liver Saturation: High doses of PRICERA saturated NAD+ levels in blood and liver, while brain and muscle did not, suggesting that liver and blood are sites of NAD+ production and transfer, whereas muscle and brain are sites of NAD+ usage.
  • Complex Metabolism: PRICERA’s pharmacodynamics differ from NR, which peaks at about eight hours post-consumption. PRICERA produces a broad elevation in NAD+ levels without a significant peak, indicating more complex metabolism involving multiple pathways.
  • Ribose Component: The proprietary ribose in PRICERA enhances pyridine salvage efficiency via PRPP, requiring less pyridine for response. This reduces the risk of overtaxing the body’s detoxification capacity, particularly in methylation and hydroxylation in the liver.
  1. Conclusion
    This study demonstrates that PRICERA effectively increases NAD+, NMN, and NR levels throughout the body with a distinct pharmacodynamic profile compared to other NAD+ boosters like NR. PRICERA’s unique composition and metabolic pathways make it a superior option for enhancing NAD+ levels efficiently and sustainably, with reduced risk of overburdening the body’s detoxification systems.

Additional Information:

  • Effective NAD+ Booster: Demonstrates superior absorption, bioavailability, and cellular efficiency compared to NMN and NR products.
  • Targets Multiple Biomarkers: Specifically designed to target NAD, Glutathione, and ATP, crucial for aging and overall health.
  • Trusted Brand: Integra Nutrition – Longevity Sciences has been a reliable name among natural health practitioners for over 25 years.

This summary captures the essential points about Pricera and its unique advantages.