GenZogenol-R

GenZogenol-R

A Broad Spectrum Telomere/Methylation Health, CRM (Calorie Restriction Mimetic) and Healthy Aging Formulation

Active Ingredients and Benefits

• Ingredients (per 900 mg. capsule)
• Resveratrol (50%) | 75 mg
• Enzogenol® | 62.5 mg
• Quercetin Dihydrate (95%) | 40 mg
• Green Tea (50 % EGCG) | 30 mg
• Lecithin | 25 mg
• Pterostilbene (95%) | 5 mg
• Astaxanthin (1.5%) | 5 mg

Each bottle contains 60 capsules: recommended dosage is 1 capsule twice a day – the dosage can be safely doubled for acute conditions.

GenZogenol-R is designed to work on and is the base product for our healthy aging protocols.

Enzogenol®, our key ingredient is expertly blended to primarily impact on DNA/telomere/methylation health with potent healthy aging properties. Primary characteristics of the synergistically blended ingredients maximize the healthy aging effects of this formulation.

The formula is a highly potent antioxidant combination of ingredients proven to provide the following health benefits:

• Preserves telomere length by up to 40% compared to controls in animal models
• Helps to prevent DNA damage
• Enhances cognitive function
• Potent anti-inflammatory properties
• Helps prevent neurodegenerative conditions and can improve existing neurodegenerative conditions
• Caloric restriction mimetic (CRM) properties
• Improves cardiovascular health (including hypotensive action)
• Maintenance of healthy cholesterol levels
• Optimizes healthy plasma glucose levels
• Exercise and performance enhancer

Mechanism of Action

NF-kappaB is a protein complex found in almost all animal cell types that controls transcription of DNA, cytokine production and cell survival and plays a key role in regulating the immune response to infection.

Nrf2 Pathway has been referred to as the master regulator of antioxidant, detoxification and cell defense gene expression. This pathway regulates the expression of a set of antioxidant and detoxifying genes, protecting the body from oxidative stress-related conditions, including (but not limited to) those affecting the brain and nervous system.

Calorie Restriction Mimetic (CRM) properties refers to ingredients that mimic caloric restriction (CR) which has been shown to provide significant anti-aging benefits in animals and humans.

PPAR gamma (peroxisome proliferator-activator receptors) is a protein that binds to DNA to increase gene expression.

• Increases insulin sensitivity and insulin secretion, which decreases blood glucose
• Increases FGF-21. FGF-21 benefiting insulin sensitivity, blood glucose and cholesterol profile
• Blocks inflammation (MAPK, NF-kappaB, and others)
• Reduces blood pressure
• Increases ApoE (Apolipoprotein E) and lowers inflammation
• Increases PON1 (R) (paraoxonase 1), an antioxidant and protects the heart

Ingredients Described

Enzogenol^® is a highly effective mixture of natural antioxidant and anti-inflammatory plant compounds extracted from the bark of New Zealand grown Pinus radiata trees using a proprietary, internationally patented, eco friendly and solvent free water-only extraction method.  It is a blend of antioxidants including oligomeric proanthocyanidins (OPC’s), catechins, quercetin, taxifolin, piceatannol, fruit acids and many other natural active ingredients .

A number of in-house and independent studies on Enzogenol® have demonstrated its numerous health benefits.  This list is too lengthy to fully detail here but here are a few examples:  it has been used extensively for Traumatic Brain Injuries (TBI’s);  vascular, skin and eye health; cardiovascular disease; and neurological health.  On request, we can provide links to a number of these studies and their findings.  Some case studies are provided in the following link: Enzogenol Case Studies Brochure®.

The most dramatic observation is the ability to lengthen telomeres (in a rat model) by over 40%!  The following link describes this study…View YouTube video on this telomere lengthening clinical study.

 Resveratrol is unique amongst antioxidants because it can safely cross the blood-brain barrier to help protect the brain and nervous system.  There is extensive research on this ingredient and many of its effects are similar to Enzogenol  which further strengthens the potency and benefit of this formula. Too numerous to list here, we reference two studies that pertain to Integra’s focus on healthy aging and age related conditions; Resveratrol and diabetes: from animal to human studies and Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial Activation

 Pterostilbene  is referred to as a methylated Resveratrol compound that is similar to and supports the benefits of Resveratrol and has a higher bioavailability and a longer period of activation in the body. It occurs naturally in blueberries and has been used for thousands of years in Ayurvedic medicine as a “blood tonic”.  Pterostilbene is well studied and some references can be found at the following link and include studies on its anti-aging properties: Pterostilbene References 

Quercetin is a flavonoid  commonly found in fruits and vegetables and it impacts many of the factors and conditions associated with aging.  As with each of our ingredients, it is supported by abundant research and it is known to address:

• Cardiovascular health (encourages blood flow and inhibits LDL oxidation)
• Can diminish levels of stress (controls chronic levels of elevated cortisol)
• Allergies, asthma and hay fever (moderates histamine release)
• Targets and combats many types of cancer
• Prostatitis
• Rheumatoid arthritis (RA)
• Blood pressure (stabilizes systolic, diastolic and average arterial pressure)
• Respiratory health
• Hypertension
• Interstitial cystitis

Green Tea (50 % EGCG) and its primary active constituent, epigallocatechin gallate (EGCG), favorably alters pathways underlying pathological processes such as:

• Cardiovascular disease – vascular protective effect: it has an impact on multiple mechanisms including antioxidative, anti-inflammatory, antithrombogenic, antiproliferative and lipid-lowering effects and activates endothelial nitric oxide synthase in cells lining blood vessels, or endothelial cells)
• Diabetes – improves glucose control and insulin sensitivity
• Cancer – inhibits a growth factor receptor called HER2, which is present in excess in about 30% of breast cancers
• Obesity – long term consumption of green tea is associated with a lower percentage of total body fat, smaller waist circumference, and decreased waist to hip ratio
• Alzheimer’s and Parkinson’s diseases – research demonstrates a neuroprotective effect in animal models

For more information, we have a number of resources including the following link: Green Tea – Protection From DNA Damage

 Astaxanthin is a carotenoid, related to beta-carotene, lutein, and canthaxanthin, and works in several unique ways.  Although most other antioxidants are depleted after they’ve transferred their free electrons,  astaxanthin has a massive surplus, allowing it to remain “active” far longer.

Also, it can quench a number of free radicals at any given time by forming an electron cloud around the molecule.  This is known as the electron dislocation resonance. When free radicals try to steal electrons from the astaxanthin molecule, they’re simply absorbed into and neutralized by this electron cloud all at once.

Research has demonstrated that is reduces oxidative damage to DNA by 40% (even at low doses).  Again, the benefits are far too numerous to list here:  a more complete summary can be found in this link: Medical Research on Astaxanthin

 Lecithin contains fatty acids that can activate gene controlling receptors (PPAR Gamma – peroxisome proliferator-activated receptors).  Once activated, these receptors play a major role in energy balance and metabolic function.  Amongst  its many health benefits, of note are the following: it improves cholesterol levels, benefits the brain, improves immunity and protects the liver.  It also improves absorption of the other ingredients.

Pathways Affected

GenZogenol-R has a positive impact on the following Biochemical Pathways / Metabolic Control Systems:

 AMPK (5’ adenosine monophosphate-activated protein kinase) is found inside every cell and serves as the body’s “master regulating switch”.  Research to date has shown:

• Extension of life span by as much as 20-30% in animals
• Modulates insulin secretion by pancreatic beta-cells improving glucose uptake in cells
• Inhibits lipogenesis and increases lipolysis
• Reduces blood triglycerides
• Decreases liver fat accumulation and fat-related chronic inflammation (down-regulating acetyl CoA carboxylase)
• Can generate new, healthy mitochondria (mitochondrial biogenesis)
• Stimulates hepatic fatty acid oxidation and ketogenesis
• Inhibition of cholesterol synthesis (down-regulating HMG CoA reductase)
• Stimulates skeletal muscle fatty acid oxidation
• Improvement in muscular performance
• Reversal of metabolic senescence
• Stimulates the MTOR pathway to enhance autophagy in muscle (a complex process that can be regarded as a form of housekeeping or remodelling)

NF-kappaB  (kappa-light-chain-enhancer of activated B cells) is a protein complex  found in almost all animal cell types that controls transcription of DNA, cytokine production and cell survival and plays a key role in regulating the immune response to infection.

 Nrf2  Pathway (Nuclear factor erythroid 2–related factor 2) has been referred to as the “master regulator of antioxidant, detoxification and cell defense gene expression…”  This pathway regulates the expression of a set of antioxidant and detoxifying genes, protecting the body from oxidative stress-related conditions, including (but not limited to) those affecting the brain and nervous system.  Please see Nrf2 Signalling Pathway:  Regulation of Antioxidants, Health Optimization, Anti-Aging for more complete information.

Calorie Restriction Mimetic (CRM) properties refers to ingredients that mimic caloric restriction (CR) which has been shown to provide significant anti-aging benefits in animals and humans

PPAR (peroxisome proliferator-activated receptors) gamma is a protein that binds to DNA to increase gene expression.  It’s actions include: 

• Increases insulin sensitivity and insulin secretion, which decreases blood glucose
• Blocks inflammation (MAPK, NF-kappaB, and others)
• Increases FGF-21. FGF-21 has been shown to benefit insulin sensitivity, blood glucose, cholesterol profile and decrease body weight Inflammation in your heart and reduces cholesterol
• Reduces blood pressure
• Increases ApoE (Apolipoprotein E) and lowers inflammation
• Increases PON1 (R) (paraoxonase 1), an antioxidant and protects the heart